Intern at Aryabhatta Research Institute of Observational Sciences (ARIES), Nainital Summer Break 2022
Studied modern instruments 206.5 MHz ST Radar and Lidar; 3.6m,130cm & 104cm Optical Telescope & 4m International Liquid Mirror Telescope (ILMT); interacted with experts to grasp the subject and current research in Astrophysics
Intern at La Renon Healthcare, Ahmedabad 2022-2023
Hands-on equipment used for manufacturing and stability studies of solid dosage forms in the pharmaceutical industry: practical application of equipment like the Tablet Punching Machine, Friability Tester, disintegration test, Dissolution test, HPLC, and GC to monitor changes in drug content over time to assess the quality and performance of the formulations.
The project involves working with
Tablet Punching Machine:
- Application: Used for the compression of powder to form tablets.
- Significance: Ensures uniform size, shape, and weight of tablets, and helps control release properties based on the compression force used.
Friability Tester:
- Application: Evaluate the ability of tablets to withstand abrasion and chipping during handling.
- Significance: Ensures the tablets are durable enough for packaging, transportation, and general handling without breaking or chipping.
Disintegration Test:
- Application: Measures the time required for a tablet to break apart in a specified environment (usually a fluid).
- Significance: Ensures that the tablet will release its active ingredient in a predictable manner once ingested. If a tablet doesn’t disintegrate properly, it might not release the drug efficiently.
Dissolution Test:
- Application: Measures the rate and extent to which the active pharmaceutical ingredient (API) is released from the tablet into a specified solvent.
- Significance: Helps in predicting how the drug will behave in vivo. If the drug doesn’t dissolve properly, it may not be bioavailable to the extent required for therapeutic effect.
HPLC (High-Performance Liquid Chromatography):
- Application: Separates, identifies, and quantifies components in a mixture.
- Significance: Used to monitor drug content, impurities, and degradation products. Ensures the quality and consistency of the formulation.
GC (Gas Chromatography):
- Application: Separates and analyzes volatile compounds in a mixture.
- Significance: Typically used for solvents and other volatile impurities. Ensures that unwanted volatile compounds are not present at unacceptable levels.
Monitoring Changes Over Time:
- To assess the stability of the formulation, samples are often stored under various conditions (e.g., different temperatures, and humidity levels) for specified durations
- Periodic testing using HPLC and GC will reveal changes in drug content, the emergence of degradation products, and any potential shift in physical properties
- The aim is to ensure that the formulation remains safe and effective throughout its shelf life
